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Upon binding to endogenous ligand acetylcholine (ACh) or nicotine, the central pore of nAChR opens to allow the flow of cations (Na + and Ca 2+ into and K + out of the cells, Figure 1B), resulting in membrane depolarization or activation of intracellular calcium-mediated signaling pathways if calcium permeability is sufficient

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In an e-cigarette, the battery powers the devices heating mechanism, which turns the liquid solution into vapor

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